![]() ![]() In Colombia, the major depressive disorder is the first cause of disease burden in women, and the second in men, after cardiovascular diseases, especially in the most productive ages ( 7). Added to the medical treatment costs are those caused by the loss of productive capacity and decreased work performance ( 6). The major depressive disorder is one of the five main factors associated with absenteeism and decreased work capacity ( 5). In Colombia, the last National Mental Health Survey conducted in 2003 showed a lifetime prevalence of mood disorders of 15.0%, with major depressive disorder being the most frequent (12.1%) ( 2).Īccording to the World Health Organization (WHO), the major depressive disorder is one of the most common causes of disability and burden of disease worldwide ( 3, 4) it is projected that it will be in the second place in 2020, and in the first place in 2030 ( 4). Lifetime prevalence of major depression episodes in the general population varies considerably among countries, although in most it is 8-12% in some, like Japan, it is 3%, and in others, like the United States, it is 16.9% ( 1). It is highly prevalent, chronic and incapacitating, it occurs frequently with comorbidities, and results in loss of productivity, increased mortality rates, and, additionally, its medical treatment is very expensive for countries. The major depressive disorder is a globally significant public health problem. Keywords: serotonin, polymorphism, genetic, depressive disorder, major, anxiety disorders, suicide, risk, comorbidity El alelo S se asoció significativamente con el trastorno de depresión mayor en pacientes menores de 37 años al ajustar por trastornos concomitantes de ansiedad. El genotipo SL se asoció con el trastorno de depresión mayor en pacientes de todas las edades. El análisis multivariado ajustado por trastornos concomitantes de ansiedad mostró una asociación significativa de la depresión mayor con el genotipo SL (p=0,049 OR=3,20 IC 95% 1,003-10,233) el alelo S estuvo cerca de la significación estadística (p=0,063 OR=2,94 IC 95% 0,94-9,13), y fue estadísticamente significativo en los casos de menores de 37 años (p=0,026 OR=10,79 IC 95% 1,32-80,36).Ĭonclusiones. Hubo diferencias significativas en menores de 37 años, con predominio del alelo S en los casos (p=0,0384 odds ratio - OR=2,75 IC 95%: 0,88-8,64). ![]() 36,8 %), y el genotipo SL fue más frecuente en los casos (SL: 45,6 % Vs. El alelo corto ( short, S) predominó en los casos comparados con los controles (S: 72,1 % Vs. Las mujeres predominaron entre los participantes (82,4 %). El trastorno de depresión mayor se diagnosticó con el cuestionario Mini-International Neuropsychiatric Interview, y, el polimorfismo 5-HTT, mediante reacción en cadena de la polimerasa (PCR). Se hizo un estudio de casos y controles pareado por sexo y edad (±5 años), con una razón de uno a uno (68:68). Determinar la asociación del polimorfismo 5-HTT con la depresión mayor en Bogotá, Colombia. El polimorfismo 5-HTT se ha asociado con el trastorno de depresión mayor, aunque el planteamiento ha generado controversia. Palabras clave: serotonina, polimorfismo genético, trastorno depresivo mayor, trastornos de ansiedad, suicidio, riesgo, comorbilidad. The S allele was significantly associated with major depressive disorder in patients under age 37, adjusted for comorbid anxiety disorders. Multivariate analysis, adjusted for comorbid anxiety disorders, showed a significant association of major depression with the SL genotype (p=0.049 OR=3.20 95% CI: 1.00-10.23) the S allele was close to statistical significance (p=0.063 OR=2.94 95% CI: 0.94-9.13), and it was statistically significant in cases under 37 years of age (p=0.026 OR=10.79 95% CI: 1.32-80.36).Ĭonclusions: The SL genotype was associated with major depressive disorder in patients of all ages. There were significant differences in those under age 37, with a predominance of the S allele in cases (p=0.038 OR=2.75 95% CI: 0.88-8.64). 36.8%), and the SL genotype was more frequent in cases (SL: 45.6% vs. The S (short) allele predominated in cases compared with controls (S: 72.1% vs. Results: Females were predominant (82.4%). Major depression was diagnosed using the Mini-International Neuropsychiatric Interview, and 5-HTT polymorphism using PCR. Materials and methods: We carried out a study of cases (n=68) matched 1:1 with controls by gender and age (±5 years). Objective: To determine the association of 5-HTT short allele with major depression in Bogotá, Colombia. Introduction: The 5-HTT short allele has been controversially associated with an increased risk of major depressive disorder. ![]()
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |